PHILADELPHIA, PA (AP) -- The Eagles had to share their day with the Phillies. That was fine with the guys in green, who openly rooted for the Phillies to win another World Series.

By the time Donovan McNabb was done throwing three touchdown passes in another NFC East rout, the Eagles had something else to share - the division lead.

McNabb and receiver DeSean Jackson put on a dynamic show Sunday as the Eagles took a 40-17 win over a mistake-prone Eli Manning and the New York Giants.

The Eagles and Cowboys are both 5-2 entering their matchup next week in Philadelphia.

"When you play these NFC East teams, you prepare for a heavyweight fight," Eagles coach Andy Reid said.

The Eagles won this one by knockout in the opener of a New York-Philly doubleheader. The Yankees and Phillies played Game 4 of the World Series across the street only hours after the Eagles' blowout victory ended.

"What a great day in Philadelphia today," Reid said. "Two games against the same city team. It's a great atmosphere for the fans of Philadelphia."

Philly continued its victorious run over NFC East teams a week after beating Washington.

However, McNabb knows the division race isn't over yet.

"The challenges are everyone has a big head and bouncing around like it's going to happen every week," McNabb said.

The Eagles dominated without running back Brian Westbrook, who sat out after he suffered a concussion in the win over the Redskins. His absence caused Reid to add a new wrinkle to the offense: a fullback. Rarely asked to carry the ball under Reid, Leonard Weaver was an integral part early and helped catch the scuffling Giants by surprise.

The Eagles needed only three plays to score when Weaver ran 41 yards up the middle for a touchdown.

"It felt spacious," Weaver said. "You don't get a whole lot of opportunities as a fullback to feel what 'open field' is."

It only got better from there for the Eagles - and their fans in the home green jerseys dotted with red Phillies caps.

The next drive - launched when Asante Samuel picked off Manning - saw tight end Brent Celek's TD catch called back on a penalty. No worries. McNabb connected with Celek on a 17-yard score two plays later for a 13-0 lead.

It's point totals such as this that make it all the more puzzling that the Eagles could go without a touchdown in a loss at lowly Oakland two weeks ago.

"When I can explain those things, I'll be undefeated," Reid said.

LeSean McCoy, Westbrook's backup, joined in the fun on a 66-yard touchdown run in the fourth quarter that made it 40-17.

New York (5-3) has lost three straight games after starting the season 5-0 for the first time since 1990. Manning continuously threw high over his receivers or was the victim of bad route running and threw two interceptions.

"You don't expect it when you win five straight," Manning said. "You're feeling good, you're feeling great and then, to lose three in a row especially, you just don't feel like you're playing your best."

The Giants, eliminated by the Eagles in the NFC divisional game last season, were still in this one late in the second quarter after Manning's 18-yard touchdown pass to Kevin Boss made it 16-7.

Five minutes were left in the half. Enough time to get to the break and regroup.

Wrong.

McNabb went deep to a wide open Jackson for a 54-yard touchdown on the first play after the kickoff. Jackson has become the top target McNabb's lacked since Terrell Owens was in town dancing after scores and stirring up the locker room.

Jackson, also a threat on punt returns, tied a team record with his sixth TD of the season of 50-plus yards.

Another overthrown Manning pass was intercepted by Quintin Demps, and McNabb needed two plays to find Jeremy Maclin on a 23-yard touchdown and a 30-7 halftime lead.

Quick strikes, long strikes. McNabb, who broke a rib in the opener and missed the next two games, threw for 240 yards and was not intercepted.

Manning brought the Giants back from a 17-point deficit in the fourth quarter to win in overtime here in 2006.

Any thoughts of a similar comeback were squashed when Domenik Hixon fumbled the second-half kickoff. The turnover set up David Akers' 35-yard field goal. He also kicked a 30-yarder in the second quarter, and the Eagles continued their streak of winning by double-digit margins.

"That's not the kind of football we teach and that's not what we're all about, but there it was again," Giants coach Tom Coughlin said.

(Copyright ©2009 by The Associated Press. All Rights Reserved.)